儿童肾脏移植中需要关注的供体因素

Donor factors for kidney transplantation in children

肾脏移植是终末期肾病(end-stage renal disease,ESRD)的最佳治疗方案。活体供肾的长期存活率更高,对ESRD患儿来说是一个更好的选择。不同供体因素,如供肾来源(活体/尸体器官)、供肾大小、人类白细胞抗原(human leukocyte antigen,HLA)相容性、供体年龄等因素都可能影响肾移植的长期预后,对于儿童患者,需要着重考虑供肾的长期存活率,尽可能降低移植风险。本文就儿童肾脏移植中需要关注的供体因素进行综述。

Kidney transplantation is an optimal treatment for children with end-stage renal disease(ESRD).There is a great diversity of donor factors,such as source of donor kidney(living/dead organ),size of donor kidney,infection of donor source,compatibility of human leukocyte antigen(HLA)and donor age,etc.The long-term prognosis of transplantation is affected.For children,it is necessary to focus upon long-term survival rate and minimize the risk of transplantation.Therefore careful consideration should be given when selecting different transplant donors.A large gap between organ supply and demand has been an ongoing global challenge.It is imperative to further the refine techniques of organ preservation and boost public awareness of organ donation.