RDW在桥本甲状腺炎诊断中的临床价值

Clinical Significance of RDW in Hashimoto’s Thyroiditis

目的探讨红细胞分布宽度(RDW)在桥本甲状腺炎诊断中的临床价值。方法选取230例桥本甲状腺炎病人为研究组,230例同期体检健康者为对照组,比较2组患者临床资料和实验室指标水平差异,观察桥本甲状腺炎患者血清RDW情况,分析RDW与桥本甲状腺炎的相关性。结果桥本甲状腺炎病人RDW、抗甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)、促甲状腺素受体抗体(TRAb)水平均高于对照组,血红蛋白含量、平均红细胞血红蛋白含量低于对照组,差异均有统计学意义(P<0.05)。采用Spearman相关分析RDW与甲状腺自身抗体之间的相关性,结果显示RDW与TGAb呈现正相关(r=0.405,P<0.05)。结论桥本甲状腺炎患者RDW增高,与TGAb呈正相关。RDW可能为监测桥本甲状腺炎发生及病情进展的新参考指标。

Objective To study the clinical significance of red blood cell volume distribution width(RDW)in the diagnosis and treatment of Hashimoto’s thyroiditis.Methods A total of 230 patients with Hashimoto’s thyroiditis were selected as study group and 230 healthy volunteers were collected as control group.The clinical data and laboratory index levels of the two groups were compared,RDW level of Hashimoto’s thyroiditis patients was observed,and the correlation between RDW and Hashimoto’s thyroiditis diagnosis index was analyzed.Results Levels of RDW,anti-thyroglobulin antibody(TGAb),thyroid peroxidase antibody(TPOAb)and thyrotropin receptor antibody(TRAb)in the Hashimoto’s thyroiditis group were higher than those in the control group,while levels of hemoglobin content and mean RBC hemoglobin content were lower(P<0.05).Spearman correlation analysis was used to analyze the correlation between RDW and thyroid autoantibodies.RDW was positively correlated with TGAb(r=0.405,P<0.05).Conclusion RDW may increase in hashimoto’s thyroiditis,and RDW is positively correlated with TGAb.RDW may be a new reference index for monitoring the occurrence and progression of Hashimoto’s thyroiditis.