血清PCT SAA CRP ALB对胰腺癌术后胰瘘的诊断价值

Diagnostic Value of the Change of Serum PCT SAA CRP and ALB in Pancreatic Fistula after Surgery for Pancreatic Cancer

目的:探讨血清降钙素原(PCT)、血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)、白蛋白(ALB)水平变化在胰腺癌术后胰瘘中的临床诊断价值。方法:将我院2015年1月至2021年1月行胰腺癌手术的83例患者作为研究对象,按照是否发生胰瘘分为胰瘘组(21例,A组)和非胰瘘组(62例,B组)。分别检测两组患者血液中的PCT、SAA、CRP、ALB水平,于手术前1d及手术后第2、4、7天抽血并进行比较。结果:两组患者的PCT、SAA、CRP、ALB水平在手术前1d比较差异无统计学意义(P>0.05)。而手术术后第2天、第4天、第7天胰瘘组的PCT、SAA、CRP水平明显高于非胰瘘组;胰瘘组的ALB水平明显低于非胰瘘组,两组相比差异均有统计学意义(P<0.05)。结论:在胰腺癌术后合并胰瘘时,血清PCT、SAA、CRP明显升高,ALB明显降低,说明血清PCT、SAA、CRP、ALB对胰腺癌术后胰瘘具有重要的辅助诊断价值。

Objective:To study the diagnostic value of the change of serum PCT,SAA,CRP and ALB in pancreatic fistula after surgery for pancreatic cancer.Methods:83 patients who underwent pancreatic cancer surgery from January 2015 to January 2021 in Affiliated Hospital of Chengde Medical College were divided into pancreatic fistula group(21 cases,group A)and non pancreatic fistula group(62 cases,group B)according to whether pancreatic fistula occurred.The levels of PCT,SAA,CRP and ALB in the blood of the two groups were measured respectively.The blood was drawn and compared on the first day before operation and the second,fourth and seventh days after operation.Results:No significant difference was found between the patients one day before operationin two groups on serum levels of PCT,SAA,CRP and ALB(P>0.05).But the patients two day after operation,four days after operation and seven days after operation in the group of pancreatic fistula on serum levels of PCT,SAA,CRP were higher than those of non-pancreatic fistula group,and on the levels of ALB was lower than those of non-pancreatic fistula group,the difference had statistically significant(P<0.05).Conclusion:When pancreatic cancer complicated with pancreatic fistula,serum PCT,SAA and CRP increased significantly,and ALB decreased significantly.This indicates that serum PCT,SAA,CRP and ALB have important diagnostic value for pancreatic fistula after pancreatic cancer surgery.