密集套扎联合小剂量聚桂醇注射治疗食管胃静脉曲张效果观察

Observation on the effect of dense ligation combined with low-dose lauromacrogol injection in the treatment of gastroesophageal varices

目的探讨密集套扎联合小剂量聚桂醇注射治疗肝硬化门脉高压症食管胃静脉曲张的临床效果。方法选取肝硬化1型食管胃静脉曲张(type 1 gastroesophageal varices,GOV1)患者110例,随机分为对照组和观察组,每组55例。对照组予以螺旋套扎联合组织胶注射治疗,观察组予以密集套扎联合小剂量聚桂醇注射治疗,比较2组疗效、套扎次数、不良反应发生情况及术后静脉曲张复发率。结果观察组首次治疗总有效率高于对照组,平均套扎次数低于对照组,术后再出血、术后疼痛、发热不良反应发生率低于对照组,差异有统计学意义(P<0.05);全部治疗完成后6个月与12个月复查胃镜观察组静脉曲张复发率低于对照组,差异有统计学意义(P<0.05),并且随着时间延长,差异性越明显。结论密集套扎联合小剂量聚桂醇注射治疗GOV1安全有效,可减少套扎次数,降低术后并发症发生率及静脉曲张复发率。

Objective To investigate the clinical efficacy of dense ligation combined with low-dose lauromacrogol injection in the treatment of gastroesophageal varices of patients with liver cirrhosis and portal hypertension.Methods A total of 110 liver cirrhosis patients with type 1 gastroesophageal varice(GOV1)were randomly divided into the control group(n=55)and the observation group(n=55).The control group was treated with spiral ligation combined with tissue glue injection,and the observation group was treated with dense ligation combined with lauromacrogol injection.The efficacy,the frequency of ligation,incidence of adverse reactions and recurrence rate of postoperative varices in the two groups were compared.Results The total effective rate of the initial treatment in the observation group was higher than that in the control group,the average frequency of ligation in the observation group was lower than that in the control group,and the incidence of postoperative rebleeding,postoperative pain,and postoperative adverse reactions including fever was lower in the observation group than in the control group,suggesting significant difference(P<0.05).The recurrence rate of varices by gastroscopy was lower in the observation group than in the control group at 6 months and 12 months after completion of treatment,and the difference was statistically significant(P<0.05);The difference was more significant with time.Conclusion Dense ligation combined with lauromacrogol injection is safe and effective in the treatment for GOV1,which can reduce the frequency of ligation,postoperative complications and recurrence rate of varices.