被动吸烟与成年非吸烟人群高血压风险的meta分析

Meta-analysis of the relationship between passive smoking and hypertension risk among non-smoking adults

目的采用meta分析的方法评估被动吸烟对成年非吸烟人群高血压风险的影响。方法系统检索PubMed、Web of Science、Embase、万方数据库、中国知网(CNKI)及维普数据库(VIP)中从建库至2021年10月发表的有关被动吸烟与成年非吸烟人群高血压风险关系的观察性研究论文,应用Stata 12.0软件进行统计学分析,计算其合并优势比值(OR)和95%置信区间(95%CI),采用剂量-反应关系对被动吸烟暴露时间与高血压的风险相关性进行量化分析。结果共纳入10篇文献,共纳入研究对象5016557人。合并分析结果显示,被动吸烟可增加成年非吸烟人群高血压的发病风险(OR=1.21,95%CI:1.08~1.35)。剂量-反应关系分析结果显示,被动吸烟暴露时间每增加1 h/d可增加高血压的风险(OR=1.09,95%CI:1.01~1.18)。结论被动吸烟是成年非吸烟人群高血压发病的危险因素。

Objective To perform a meta-analysis of the effects of passive smoking on risk of hypertension among non-smoking adults. Methods PubMed, Web of science, Embase, Wanfang database, CNKI and VIP database were systematically searched for observational studies on the association between passive smoking and risk of hypertension among non-smoking adults. Retrieval time for literatures was from the establishment of each database to October 2021. Stata 12.0 software was used to calculate combined odds ratio(OR) and the 95% confidence interval(CI). Dose-response analysis was conducted to quantify the correlation between duration of passive smoking exposure and risk of hypertension. Results A total of 10 studies were included in this meta-analysis, involving 5,016,557 participants. The combined analysis results showed that passive smoking could increase risk of hypertension among non-smoking adults(OR=1.21, 95%CI:1.08-1.35). Dose-response analysis revealed that an increase of 1 h/d passive smoking exposure was associated with an increase in risk of hypertension(OR=1.09, 95%CI:1.01-1.18). Conclusion Passive smoking is a significant risk factor of hypertension among non-smoking adults.