摘要
光遗传学技术是指利用光控蛋白对特定基因进行光学控制的一种技术,具有高度的时间和空间特异性。光遗传学技术在心血管疾病、视听障碍、代谢性疾病和神经系统疾病等临床治疗研究中均有广泛的应用,在基础医学的研究中也逐渐成为热点技术。近年来,光遗传学技术在口腔医学领域中的应用也逐渐增多,如味觉系统的研究、三叉神经痛的治疗、颌面部肌肉神经支配的研究等。本文就光遗传学技术在口腔医学中的应用作一综述。
Optogenetics technology refers to a technology that uses photosensitive proteins of high spatial-temporal specificity to optically control specific genes.Optogenetics technology has been widely used application in researches of clinical treatment targeted at cardiovascular diseases,visual and auditory disorders,metabolic diseases and neurological diseases.Moreover,it has developed into a hotspot technology in fundamental medical researches.Recently,applications of optogenetics technology in the field of stomatology have been gradually increasing,such as the study of taste system,the treatment of trigeminal neuralgia,the study of maxillofacial muscle innervation,etc.This article reviews applications of optogenetics in stomatology.
作者
傅梦蝶
朱丹吉
杨国利
姜治伟
FU Mengdie;ZHU Danji;YANG Guoli;JIANG Zhivei(Stomatology Hospial,School of Stomalology,Zhejiang University School of Medicine,Clinical Research Center for Oral Diseases of Zhejiang Province,Key Laboratory of Oral Biomedical Research of Zhejiang Prou-ince,Cancer Center of Zhejiang University,Hangzhou 310006,China)
出处
《口腔医学》
CAS
2022年第4期354-357,共4页
Stomatology
基金
国家自然科学基金面上项目(81901051)。
关键词
光遗传学
味觉系统
三叉神经痛
颌面部肌肉运动
口腔医学
optogenetics
taste system
trigeminal neuralgia
maxillofacial muscle movement
stomatology
