摘要
Integrin molecules are transmembraneαβheterodimers involved in cell adhesion,trafficking,and signaling.Upon activation,integrins undergo dynamic conformational changes that regulate their affinity to ligands.The physiological functions and activation mechanisms of integrins have been heavily discussed in previous studies and reviews,but the fluorescence imaging techniques-which are powerful tools for biological studies-have not.Here we review the fluorescence labeling methods,imaging techniques,as well as Förster resonance energy transfer assays used to study integrin expression,localization,activation,and functions.
出处
《BIOCELL》
SCIE
2021年第2期229-257,共29页
生物细胞(英文)
基金
This work was supported by funding from the National Institutes of Health,USA(NIH,R01HL145454)
a startup fund from UConn Health.