超声靶向微泡破坏技术介导自杀基因在恶性肿瘤中的研究进展

Research progress of ultrasound-targeted microbubble destruction technology mediated suicide genes in malignant tumors

恶性肿瘤在全球的发病率和死亡率逐年上升,严重威胁人类的健康。自杀基因疗法为各种类型的恶性肿瘤提供了一种极具前景的治疗手段。超声靶向微泡破坏(UTMD)技术为自杀基因的传递赋予了新的方式。本文就UTMD技术介导的自杀基因转染在恶性肿瘤治疗中的研究进展进行综述。

Malignant tumor is an important cause of morbidity and mortality worldwide,which poses a serious threat to human health.Suicide gene therapy offers a highly promising treatment for various forms of malignancy.Ultrasound-targeted microbubble destruction(UTMD)technology provides a new way for suicide genes delivery.This article reviews the research progress of UTMD-mediated suicide genes transfection in the treatment of malignant tumors.