慢性阻塞性肺疾病合并肠道功能障碍研究进展

Research Progress of Chronic Obstructive Pulmonary Disease with Intestinal Dysfunction

慢性阻塞性肺疾病(COPD)是一种病因和发病机制尚未完全明确的慢性复发性肺部疾病,常引发多种肺外并发症,而肠道功能障碍作为常见肺外表现之一,是近期的研究热点。本文在翻阅中医古籍及现代医学研究成果的基础上,一方面系统阐释了COPD病程中肺与大肠交互影响的中医理论和病机,另一方面论述了肺肠共同的生理起源及可能的病理学机制,深入探讨了COPD与相关性肠道功能障碍的关系,以期为COPD的临床有效防控提供科学、可靠的理论依据和诊疗思路。

Chronic obstructive pulmonary disease(COPD) is a chronic recurrent pulmonary disease with the etiology and pathogenesis had not been fully defined, which often caused variety of extrapulmonary complications and intestinal dysfunction, and to be a hotspot in recent research. Based on the research results from traditional Chinese medicine and modern medicine, the interaction theory and pathogenesis of the lung and large intestine for the COPD were system illustrated. On the other hand, the lung intestinal common physiological origins and possible mechanism of pathology were deeply discussed between COPD and the correlation of bowel dysfunction, so as to provide scientific, reliable, theoretical and diagnosis for treatment of COPD in clinical trial.