纤维素/无机复合材料:纤维素及其衍生物的矿化与应用

Organic/inorganic composite materials: mineralization and applications of cellulose and its derivatives

纤维素及其衍生物与羟基磷灰石(HA)的复合材料可以协同两者优势,兼具纤维素的结构、功能性和柔韧性与HA的耐热性、稳定性和生物相容性等。纤维素/HA复合材料常用的矿化方法主要有原位矿化法和仿生矿化法,仿生矿化合成的HA一般具有更高的表面积、表面粗糙度以及更显著的生物活性和可吸收性。纤维素还可以通过不同的交联策略和化学改性调节HA晶体的生长取向和形貌。本文主要综述了纤维素/HA复合材料的研究进展,对纤维素及HA的性质、纤维素对HA的矿化调控进行了归纳总结,重点介绍了纤维素/HA复合材料在水处理吸附剂、药物传输系统、骨组织工程等方面的研究现状,并对目前研究中界面理论的缺失以及未来的研究方向进行了分析和展望。

Cellulose and its derivatives composited with hydroxypatite(HA) can create synergistic effects, which can combine the structure, functionality and flexibility of cellulose and the heat resistance, stability and biocompatibility of HA. The commonly used methods for preparing cellulose/HA composite mainly are the biomimetic mineralization and in-situ mineralization, of which the HA synthesized by biomimetic mineralization generally has nanoscale size and morphology, higher surface area and surface roughness, exhibiting more significant biological activity and absorbability. Cellulose can also adjust the crystal orientation and morphology of HA by different crosslinking strategies and chemical modification methods. This review article covers the current knowledge about the cellulose/HA composite materials and summarizes the properties of cellulose and HA as well as the regulation of HA mineralization by cellulose. The research status of cellulose/HA composite materials are highlighted in water treatment adsorbents, drug delivery systems and bone tissue engineering. Finally, the missing of interfacial theory is analyzed and the future research directions are prospected.