血清谷胱甘肽-S-转移酶和胎盘生长因子水平与急性脑梗死患者预后的相关性分析

Correlation between serum glutathione-S-transferase and placental growth factor levels and prognosis of patients with acute cerebral infarction

目的探讨血清谷胱甘肽-S-转移酶(GST)、胎盘生长因子(PLGF)水平与急性脑梗死患者预后的相关性。方法选取2018年8月至2020年2月本院收治的80例急性脑梗死患者作为研究对象,均应用格拉斯哥预后量表(GOS)评估预后情况,并根据其结果分为预后不良组(n=24)和预后良好组(n=56)。采用酶联免疫吸附测定法检测患者入院时血清GST、PLGF水平,分析血清GST、PLGF水平与急性脑梗死患者预后的相关性;绘制受试者工作特征(ROC)曲线,观察曲线下面积(AUC),分析血清GST、PLGF水平评估急性脑梗死患者的预后价值。结果80例急性脑梗死患者中预后良好56例(70.00%),预后不良24例(30.00%)。预后良好组与预后不良组性别、年龄、发病至入院时间、入院时收缩压(SBP)、入院时舒张压(DBP)、入院时脑梗死面积及入院时美国国立卫生研究院卒中量表(NIHSS)评分比较差异无统计学意义;预后不良组血清GST水平明显低于预后良好组,而PLGF水平明显高于预后良好组,差异有统计学意义(P<0.05)。Logistics回归分析显示,血清GST水平降低、PLGF水平升高是急性脑梗死患者预后不良的危险因素(OR>1,P<0.05)。ROC曲线显示,血清GST、PLGF水平评估急性脑梗死患者预后的AUC值为0.815、0.833,评估价值均较好。结论急性脑梗死患者血清GST水平降低、血清PLGF水平升高会增加其预后不良的发生风险,且血清GST、PLGF水平预测急性脑梗死患者预后价值较好,故检测血清GST、PLGF水平并及时实施干预措施,对改善患者预后具有重要意义。

Objective To investigate the correlation between serum glutathione-S-transferase(GST)and placental growth factor(PLGF)levels and the prognosis of patients with acute cerebral infarction.Methods 80 patients with acute cerebral infarction treated in our hospital from August 2018 to February 2020 were selected as the research subjects,the prognosis was evaluated by Glasgow outcome scale(GOS),and they were divided into poor prognosis group(n=24)and good prognosis group(n=56)according to the results.The levels of serum GST and PLGF were detected by en-zymelinked immunosorbent assay,and the correlation between the levels of serum GST and PLGF and the prognosis of patients with acute cerebral infarction was analyzed;the receiver operating characteristic(ROC)curve was drawn,the area under curve(AUC)was observed,the levels of serum GST and PLGF,and evaluate the prognostic value of patients with acute cerebral infarction was analyzed.Results Among the 80 patients with acute cerebral infarction,56 cases(70.00%)had good prognosis and 24 cases(30.00%)had poor prognosis.There was no significant difference in gender,age,time from onset to admission,systolic blood pressure(SBP),diastolic blood pressure(DBP),cerebral infarction area and NIHSS score between the good prognosis group and the poor prognosis group;the level of serum GST in the poor prognosis group was significantly lower than that in the good prognosis group,while the level of PLGF was significantly higher than that in the good prognosis group(P<0.05).Logistic regression analysis showed that the decrease of serum GST level and the increase of PLGF level were the risk factors for poor prognosis in patients with acute cerebral infarction(OR>1,P<0.05).The results of ROC curve showed that the AUC value of serum GST and PLGF levels in evaluating the prognosis of pa-tients with acute cerebral infarction were 0.815 and 0.833,which were of good evaluation value.Conclusion The low level of serum GST and high level of serum PlGF in patients with acute cerebral infarction will increase the risk of poor prognosis,and the level of serum GST and PLGF has a good value in predicting the prognosis of patients with acute cerebral infarction.Therefore,it is great significance important to detect the level of se-rum GST and PLGF and timely implementation of intervention measures to improve the prognosis of patients.