比较帕拉米韦与炎琥宁对儿童流行性感冒发热的临床疗效及C反应蛋白水平的影响

Comparison of the clinical efficacy of peramivir and potassium sodium dehydroandrograpolide succinate on children with influenza fever and the effect on C reactive protein levels

目的比较帕拉米韦与炎琥宁对儿童流行性感冒发热的临床疗效及C反应蛋白(CRP)水平的影响。方法选取2019年6月至2020年5月本院收治的92例儿童流行性感冒发热患儿作为研究对象,按照随机数字表法分为观察组和对照组,各46例。对照组给予炎琥宁静脉滴注治疗,观察组给予帕拉米韦静脉滴注治疗,比较两组患儿临床疗效、治疗前后CRP水平及临床症状缓解时间。结果观察组治疗总有效率为93.48%,明显高于对照组的78.26%,差异有统计学意义(P<0.05)。治疗前,两组CRP水平比较差异无统计学意义;治疗后,两组CRP水平均明显低于治疗前,且观察组[(2.21±0.23)mg/L]低于对照组[(4.43±0.31)mg/L],差异有统计学意义(P<0.05)。观察组咳嗽、鼻塞、发热、咽喉痛等症状缓解时间均短于对照组,差异有统计学意义(P<0.05)。结论与炎琥宁比较,采用帕拉米韦治疗儿童流行性感冒发热患儿临床疗效更佳,可有效降低机体CRP水平,缩短症状缓解时间,值得临床推广应用。

Objective To compare the clinical efficacy of peramivir and potassium sodium dehydroandrograpolide succinate on children with influenza fever and their effect on C reactive protein(CRP levels.Methods 92 children with influenza fever were treated in our hospital from June2019 to May 2020 were selected as the research subjects,and they were divided into observation group and control group according to the random number table method,with 46 cases in each group.The control group was given potassium sodium dehydroandrograpolide succinate intravenous drip therapy,and the observation group was given peramivir intravenous drip therapy,the clinical efficacy,CRP levels before and after treatment,and relief time of clinical symptoms were compared between the two groups.Results The total effective rate of the observation group was 93.48%,which was significantly higher than that 78.26%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in CRP levels between the two groups;after treatment,the CRP levels in the two groups were lower than those before treatment,and the observation group([2.21±0.23]mg/L)was lower than the control group([4.43±0.31])mg/L),and the difference was statistically significant(P<0.05).The remission time of cough,nasal congestion,fever,sore throat and other symptoms in observation group was significantly shorter than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with potassium sodium dehydroandrograpolide succinate,the clinical efficacy of peramivir in the treatment of children with influenza fever is better,and it can effectively reduce the level of CRP and shorten the time of symptom relief,which is worthy of clinical application.