“脑心互损”过程炎症介质与活血化瘀方作用机制研究进展

Research Progress on Inflammatory Factors of Brain-Heart Damage and the Mechanism of Huoxue Huayu Prescription

脑病及心,心病及脑,脑心互损的病理机制成为当今研究的热点之一。脑缺血发生后通过“下丘脑-垂体-肾上腺”轴、瀑布级联反应以及交感神经与副交感神经的紊乱等影响心脏功能。心肌缺血后炎性细胞的浸润、心室重构等加重全身性炎症反应,造成星形胶质细胞、小胶质细胞的增生、炎症介质的分泌引起脑损伤。随着研究的不断深入,炎症反应被认为是脑与心损伤的重要环节之一。因此本文结合国内外相关文献,从炎症介质以及活血化瘀方作用机制进展进行总结,为中医脑心相关理论研究及“脑心同治”科学内涵的揭示提供参考。

The pathological mechanisms of encephalopathy involving heart,heart disease involving brain,and brain-heart damage have become the hotspots of current research.The occurrence of cerebral ischemia affects cardiac functions by the hypothalamic-pituitary-adrenal axis,cascade reaction,and disturbance of sympathetic and parasympathetic nerves.The infiltration of inflammatory cells and ventricular remodeling after myocardial ischemia aggravate the systemic inflammatory response,causing the proliferation of astrocytes and microglia and the secretion of inflammatory cytokines and thus resulting in brain damage.With the deepening of research,inflammatory response is considered to be an important link in brain and heart injury.Therefore,this paper summarized the research progress of inflammatory factors and the mechanism of Huoxue Huayu Prescription with reference to relevant literature in China and abroad,which provided reference for studying brain-heart theories and elucidating simultaneous treatment of brain and heart in traditional Chinese medicine.