肺部感染评分联合血清降钙素原在指导老年重症肺炎患者合理使用抗生素中的应用研究

Application of pulmonary infection score combined with serum procalcitonin in guiding rational use of antibiotics in elderly patients with severe pneumonia

目的探讨临床肺部感染评分(CPIS)联合血清降钙素原(PCT)在指导老年重症肺炎(SP)患者合理使用抗生素中的应用效果。方法选择我院住院治疗的老年SP患者120例,采用随机数字表法分为试验组62例和对照组58例。对照组由医师根据临床经验选择抗生素及治疗方案,试验组根据CPIS、PCT动态评估结果选择抗生素及治疗方案,比较两组抗生素使用情况、住院时间与住院费用、临床疗效、真菌定植率。结果试验组抗生素使用种类、总住院费用低于对照组,抗生素使用时间、并发症控制时间、住院时间短于对照组;治疗有效率高于对照组,真菌定植率低于对照组(P<0.05)。结论CPIS联合PCT用药指导有助于减少老年SP患者抗生素使用种类,缩短抗生素使用时间及住院时间,降低真菌感染发生率,提高治疗效果。

Objective To investigate the application effect of clinical pulmonary infection score(CPIS)combined with serum procalcitonin(PCT)in guiding the rational use of antibiotics in elderly patients with severe pneumonia(SP).Methods One hundred and twenty elderly patients with SP in our hospital were divided into an experimental group(n=62)and a control group(n=58)by random number table method.The control group selected antibiotics and treatment regimens by physicians according to clinical experience.The experimental group selected antibiotics and treatment regimens by physicians according to CPIS and PCT evaluation results.The use of antibiotics,hospitalization time and cost,clinical efficacy,and fungal colonization rate were compared between the two groups.Results Antibiotic types and total hospitalization cost were lower in the experimental group than those in the control group.The antibiotic use time,complication control time,and hospitalization time were shorter in the experimental group than those in the control group.The effective rate was higher in the experimental group than that in the control group.The fungal colonization rate was lower in the experimental group than that in the control group.All differences were statistically significant(P<0.05).Conclusion CPIS combined with PCT guidance helps to reduce the antibiotic types,shorten the antibiotic use time and hospitalization time,improve the therapy effect,and reduce the fungal infection.It improves treatment effect.