左氧氟沙星联合阿奇霉素治疗宫颈炎的临床效果及安全性

Clinical effect and safety of levofloxacin combined with azithromycin in the treatment of cervicitis

目的观察左氧氟沙星联合阿奇霉素治疗宫颈炎的临床效果及安全性。方法回顾性选取2019年1月—2020年12月湖北省麻城市妇幼保健院收治的宫颈炎患者78例,根据治疗方式不同分为研究组和对照组,每组39例。对照组给予阿奇霉素治疗,研究组给予左氧氟沙星联合阿奇霉素治疗,2组患者均治疗14 d。比较2组患者临床疗效,治疗前后实验室相关指标[血管内皮生长因子(VEGF)、自然杀伤T细胞(NKTs)]、炎性因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)]、生活质量评分及不良反应。结果治疗14 d后,研究组患者总有效率为92.31%,高于对照组的69.23%(χ^(2)=6.686,P=0.009);2组患者VEGF及NKTs水平均高于治疗前,且研究组高于对照组(P<0.01);2组患者TNF-α、hs-CRP及IL-6水平均低于治疗前,且研究组低于对照组(P<0.01);2组患者各项生活质量评分均高于治疗前,且研究组高于对照组(P<0.01);2组患者不良反应总发生率比较差异无统计学意义(χ^(2)=1.130,P=0.287)。结论左氧氟沙星联合阿奇霉素治疗宫颈炎的临床效果较好,可显著降低机体炎性反应,改善患者临床症状,加快疾病康复进程,提高患者生活质量,值得临床应用。

Objective To observe the clinical effect and safety of levofloxacin combined with azithromycin in the treatment of cervicitis.Methods A total of 78 patients with cervicitis who were admitted to Macheng Maternal and Child Health Hospital in Hubei Province from January 2019 to December 2020 were retrospectively selected and divided into study group and control group according to different treatment methods,with 39 cases in each group.The control group was treated with azithromycin,and the study group was treated with levofloxacin combined with azithromycin,both groups were treated for 14 d.The clinical efficacy,laboratory-related indexes[vascular endothelial growth factor(VEGF),natural killer T cells(NKTs)],inflammatory factors[tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)],quality of life scores and adverse reactions before and after treatment were compared between the two groups.Results After 14 days of treatment,the total effective rate was 92.31%in the study group,which was higher than 69.23%in the control group(χ^(2)=6.686,P=0.009);The levels of VEGF and NKTs in both groups were higher than those before treatment,and the study group was higher than the control group(P<0.01);The levels of TNF-α,hs-CRP and IL-6 in the two groups were lower than those before treatment,and the study group was lower than the control group(P<0.01);The quality of life scores of the two groups were higher than those before treatment,and the study group was higher than the control group(P<0.01);There was no significant difference in the total incidence of adverse reactions between the two groups(χ^(2)=1.130,P=0.287).Conclusion The clinical effect of levofloxacin combined with azithromycin in the treatment of cervicitis is good,which can significantly reduce the inflammatory response of the body,improve the clinical symptoms of patients,speed up the process of disease recovery,and improve the quality of life of patients,which is worthy of clinical application.