重组人干扰素α-2b雾化吸入治疗老年院内感染的临床疗效

Clinical efficacy of recombinant human interferonα-2b inhalation in the treatment of elderly patients with nosocomial infection

目的观察重组人干扰素α-2b雾化吸入治疗老年院内感染的临床疗效。方法选取2018年6月—2019年12月于山西省大同市第五人民医院呼吸与危重症医学科住院的老年(≥60岁)院内感染患者50例,按照随机数字表法分为观察组和对照组,每组25例。对照组采用常规治疗,观察组在常规治疗的基础上给予重组人干扰素α-2b雾化吸入,2组患者均治疗7 d。比较2组患者临床疗效、临床症状及体征缓解时间、治疗前后实验室指标。结果观察组患者总有效率为96.00%,高于对照组的76.00%(χ^(2)=4.153,P=0.042);观察组患者止咳时间、退热时间、咯痰消失时间、啰音消失时间均短于对照组(P<0.01);治疗7 d后,2组患者C反应蛋白(CRP)、降钙素原(PCT)、红细胞沉降率(ESR)、白细胞计数(WBC)、中性粒细胞计数均低于治疗前,淋巴细胞计数均高于治疗前,且观察组降低/升高幅度大于对照组(P<0.01)。结论重组人干扰素α-2b雾化吸入治疗老年院内感染的效果较好,可在临床应用推广。

Objective To observe the clinical effect of recombinant human interferonα-2b inhalation in the treatment of elderly patients with nosocomial infection.Methods A total of 50 elderly patients(≥60 years old)with nosocomial infection who were hospitalized in the Department of Pulmonary and Critical Care Medicine,the Fifth People′s Hospital of Datong,Shanxi Province from June 2018 to December 2019 were selected,and they were divided into observation group and control group according to the random number table method,25 cases in each group.The control group was given routine treatment,and the observation group was given recombinant human interferonα-2b mist inhalation on the basis of routine treatment,both groups were treated for 7 days.The clinical efficacy,remission time of clinical symptoms and signs,and laboratory indexes before and after treatment were compared between the two groups.Results The total effective rate of patients in the observation group was 96.00%,which was higher than 76.00%in the control group(χ^(2)=4.153,P=0.042);The antitussive time,antipyretic time,expectoration disappearance time and rales disappearance time in the observation group were shorter than those in the control group(P<0.01);After 7 days of treatment,the levels of C-reactive protein(CRP)、procalcitonin(PCT)、erythrocyte sedimentation rate(ESR)、white blood cell(WBC)and neutrophil counts in the two groups were all lower than those before treatment,and the counts of lymphocytes were all higher than those before treatment,and the decrease/increase extent of the observation group was greater than that of the control group(P<0.01).Conclusion The atomization of recombinant human interferonα-2b in the treatment of nosocomial infection in elderly inpatients has a significant effect,and can be applied in clinical treatment and further promoted.