六味地黄丸治疗围绝经期综合征的临床研究进展

Research advances in clinical effect of Liuwei Dihuang Pill in treatment of menopausal syndrome

围绝经期综合征是女性绝经前后的常见疾病,临床研究发现六味地黄丸治疗该病具有较好的疗效。经典名方六味地黄丸由熟地黄、山茱萸、山药、泽泻、牡丹皮、茯苓6味中药组方,可有效改善患者的血管舒缩、情绪失常、睡眠障碍、脂代谢紊乱、骨质流失等症状,其药效机制可能在于调节患者的雌激素水平,进而改善患者全身症状。综述六味地黄丸治疗围绝经期综合征的临床研究进展,以期为后续临床和实验研究提供参考。

Menopausal syndrome is a common disease of women, that occur during the perimenopausal and early postmenopausal period. Liuwei Dihuang Pill has been found to have obvious therapeutic effects on the disease. This classic formula is composed of six traditional Chinese herbs, including Rehmanniae Radix Praeparata, Corni Fructus, Dioscoreae Rhizoma, Alismatis Rhizoma,Moutan Cortex, Poria, which improves body composition in patients with menopausal syndrome, including vasomotor symptoms,mood disturbances, interrupted sleeping patterns, lipid metabolism disorders, bone loss, genitourinary symptoms and others. Its mechanism may lie in regulating the estrogen of patients, thereby improving the systemic symptoms of patients, hoping to provide directions and references for future research.