放射治疗组织填充物的研究进展

Research progress on bolus materials used for radiotherapy

在使用高能射线治疗皮肤表面附近的病变时,由于高能射线的剂量建成效应,需要在皮肤表面放置组织填充物(bolus)以增加表皮剂量。目前,手工制作的bolus摆位重复性较差,商品化的bolus与不规则皮肤之间存在空气间隙。3D打印具有可个性化定制、自动化制作复杂形状bolus的优势。本文主要回顾了手工制作、商品化、3D打印bolus材料的现状及未来的发展趋势,为临床工作提供参考。

It is necessary to place bolus on skin to increase the surface dose when using high-energy rays to treat superficial lesions because of its build-up effect.It is well known that the set-up reproducibility of hand-made bolus is poor,and the main concern of commercialized bolus is the inadvertent air gap between the bolus and irregular skin.Owing to the advantage of making individualized and complex-shaped bolus,3D-printing technology is playing an important role in making the bolus.The aim of this review is to summarize the current research status of hand-made,commercialized and 3D-printed bolus materials and future development trend of the bolus,providing reference for clinical application.