尿肿瘤标志物联合检测在膀胱癌早期诊断中的应用

Application of Combined Detection of Urinary Tumor Markers in Early Diagnosis of Bladder Cancer

目的:分析在膀胱癌早期诊断的过程中应用尿肿瘤标志物联合检测的价值和意义。方法:选取2019年7月-2021年10月监利市第五人民医院收治的70例膀胱癌患者作为观察组,同期收治的70例泌尿系统急性感染患者设为参照组,针对参照组泌尿系统急性感染患者和观察组膀胱癌患者分别实施尿肿瘤标志物联合检测的诊断,分析两组观察对象检测后尿肿瘤标志物联合检测对于诊断膀胱癌的价值和意义。结果:观察组膀胱癌患者检测后的NMP22水平、CD44水平、CK20水平、BTA表达、CEACAM1水平显著高于参照组泌尿系统急性感染患者,差异有统计学意义(P<0.05);观察组患者的尿肿瘤标志物检测准确性与病理学诊断结果比较,差异无统计学意义(P>0.05)。结论:在膀胱癌早期诊断的过程中给予尿肿瘤标志物联合检测的诊断价值较为显著,能为疾病的确诊和治疗提供相应的参考依据,促进患者预后。

Objective:To analyze the value and significance of combined detection of urinary tumor markers in the early diagnosis of bladder cancer.Methods:Seventy patients with bladder cancer admitted to Jianli Fifth People's Hospital from July 2019 to October 2021 were selected as the observation group,and 70 patients with acute urinary system infection admitted during the same period were selected as the reference group.The patients with acute urinary system infection in the reference group and patients with bladder cancer in the observation group were diagnosed by using the combined detection of urinary tumor markers.The value and significance of combined detection of urinary tumor markers in the diagnosis of bladder cancer were analyzed in two groups after detection.Results:The levels of NMP22,CD44,CK20,BTA expression and CEACAM1 of patients with bladder cancer in the observation group were significantly higher than those of patients with acute urinary system infection in the reference group after detection,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the detection accuracy of urinary tumor markers and pathological diagnosis results for patients in the observation group(P>0.05).Conclusion:The diagnostic value of combined detection of urinary tumor markers in the early diagnosis of bladder cancer is more significant.It can provide reference for the diagnosis and treatment of the disease and promote the prognosis of patients.