脓毒症患者血清LGALS3BP、FGF-21和Trx-1表达及其预后的关系

The expression of serum LGALS3BP,FGF-21,Trx-1 and their relationship with prognosis in patients with sepsis

目的:探讨脓毒症患者血清半乳糖凝集素-3结合蛋白(LGALS3BP)、成纤维细胞生长因子-21(FGF-21)、硫氧还蛋白-1(Trx-1)表达及其预后的关系。方法:选取2019年1月-2021年5月期间在我院重症医学科接受治疗的脓毒症患者135例作为观察组。同期,另选取我院体检健康志愿者100例作为对照组。采用酶联免疫吸附法检测各组血清LGALS3BP、FGF-21、Trx-1表达水平。根据脓毒症患者28 d的预后情况,将其分为存活组(100例)和死亡组(35例)。采用多因素logistic回归分析影响脓毒症患者死亡的危险因素。应用ROC曲线,分析LGALS3BP、FGF-21、Trx-1对脓毒症患者死亡的预测价值。结果:与对照组相比,观察组血清LGALS3BP、FGF-21、Trx-1水平明显升高,差异有统计学意义(P<0.05)。死亡组APACHEⅡ评分、SOFA评分、血清LGALS3BP、FGF-21、Trx-1水平分别与生存组相比,差异有统计学意义(P<0.05)。Pearson相关性分析示,血清LGALS3BP、FGF-21、Trx-1分别与APACHEⅡ评分、SOFA评分呈正相关(P<0.05)。多因素logistic回归分析示,APACHEⅡ评分、SOFA评分及血清LGALS3BP、FGF-21、Trx-1升高是脓毒症患者死亡的重要危险因素(P<0.05)。ROC曲线示:APACHEⅡ评分、SOFA评分及血清LGALS3BP、FGF-21、Trx-1预测脓毒症患者死亡的曲线下面积分别为0.777、0.754、0.802、0.783、0.825。结论:脓毒症患者血清LGALS3BP、FGF-21、Trx-1表达升高,并与患者的不良预后有关,对预测脓毒症患者28 d死亡具有较高的临床价值。

Objective:To investigate the expression and prognosis of serum galectin-3 binding protein(LGALS3 BP),fibroblast growth factor-21(FGF-21),and thioredoxin-1(Trx-1) in patients with sepsis relation.Methods:One hundred and thirty five sepsis patients(observation group) who were treated in our department from January 2019 to May 2021 were selected.During the same period,another 100 healthy volunteers(control group) were selected for physical examination in our hospital.Enzyme-linked immunosorbent assay was used to detect the expression levels of serum LGALS3 BP,FGF-21 and Trx-1 in each group.According to the 28-day prognosis of patients with sepsis,they were divided into survival group(n=100) and death group(n=35).Multivariate logistic regression was used to analyze the risk factors that affect the death of patients with sepsis.The ROC curve was used to analyze the predictive value of LGALS3 BP,FGF-21,Trx-1 on the death of patients with sepsis.Results:Compared with the control group,the serum LGALS3 BP,FGF-21 and Trx-1 levels in the observation group were significantly increased,and the difference was statistically significant(P<0.05).Compared with the survival group,the APACHEⅡ score,SOFA score,serum LGALS3 BP,FGF-21 and Trx-1 levels in the death group were significantly different(P<0.05).Pearson correlation analysis showed that serum LGALS3 BP,FGF-21,Trx-1 were positively correlated with APACHEⅡ score and SOFA score(P<0.05).Multivariate logistic regression analysis showed that APACHEⅡ score,SOFA score,and elevated serum LGALS3 BP,FGF-21,Trx-1 were important risk factors for death in patients with sepsis(P<0.05).The ROC curve showed that the APACHE Ⅱ score,SOFA score and serum LGALS3 BP,FGF-21,Trx-1 predicted the death of sepsis patients with AUC of 0.777,0.754,0.802,0.783,and 0.825,respectively.Conclusion:Serum LGALS3 BP,FGF-21 and Trx-1 expressions are elevated in patients with sepsis,which are related to the poor prognosis of patients.It has high clinical value in predicting the death of patients with sepsis at 28 days.