摘要
肌少症可引起老年人骨骼肌水平的显著变化,导致相关疾病发病率增加,并影响老年人的生活质量。有关肌少症的发病原因及机制与遗传、内分泌紊乱、肌纤维数量减少、营养缺乏、炎症、免疫功能紊乱等因素密切相关。肠道微生态作用于肌少症的研究所取得进展为肌少症的预防与治疗提供潜在靶点。
Sarcopenia causes significant changes inskeletal muscle mass and function in the elderly,and leads to an increased incidence of related diseases,which has affected the quality of life in the elderly.The causes and mechanisms of sarcopenia are closely related to genetic and innate factors,endocrine disorders,reduced number of muscle fibers,nutritional deficiency,inflammation,immune dysfunction and other factors.This paper systematically describes the progress of studying the effects of intestinal microecology on sarcopenia,so as to provide potential targets for the prevention and treatment of sarcopenia.
作者
周张宁
张勤
归崎峰
杨云梅
Zhou Zhangning;Zhang Qing;Gui Qifeng;Yang Yunmei(Department of Geriatrics,the First Affiliated Hospital of Medical College of Zhejiang University,Hangzhou 310003,China;The current work unit is Department of General Medicine and Department of Geriatrics,Huzhou Central Hospital,Huzhou 313000,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2022年第5期610-613,共4页
Chinese Journal of Geriatrics
基金
国家自然科学基金(81771498)
国家重点基础研究发展计划(2018YFC2000500)
浙江省医药卫生科研基金(2017KY1002040)
浙江省中医药管理局基金(2017XKA31)。
关键词
肌少症
肠道微生态
Sarcopenia
Intestinal microecology
