摘要
Recently,a study published in Nature by Domizio et al.1 revealed the underlying mechanism of aberrant immunopathology during the late phase of infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The authors provided evidence demonstrating that stimulator of interferon genes(STING)plays a unique role in the alveolus-capillary cytokine storm induced by mitochondrial DNA(mtDNA)during coronavirus disease 2019(COVID-19)(Fig.1).Some studies stressed that the STING agonists block the SARS-CoV-2 infection via triggering the type I interferons(IFNs)response,2,3 while others revealed that SARS-CoV-2 induces the chromatin DNA traveling to cytosol by promoting the cell-tocell fusion,resulting in the activation of cGAS-STING signaling.
基金
a special program from the Ministry of Science and Technology of China(2021YFA1101000)
the Chinese National Natural Science Funds(31925013 and U20A20393 to L.Z.,31871405,32125016 and 82041009 to F.Z.)
Zhejiang Provincial Natural Science Foundation of China under Grant(LBY21H060001 to L.Z.)
the Medical and the Medical and Health Research Project of Zhejiang Province(2020RC115 to L.Z.)
Jiangsu National Science Foundation(BK20180043 and 19KJA550003 to F.Z.)
the Zhejiang Natural Science Fund(LD19C070001 to L.Z.)
the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003)
Adjunct Talent Fund of Zhejiang Provincial People's Hospital and A project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions。
