电针治疗对急性脑梗死患者血清神经元特异性烯醇化酶的影响分析

Effect of electroacupuncture on serum neuron specific enolase in patients with acute cerebral infarction

目的探讨急性脑梗死患者采用电针治疗对血清神经元特异性烯醇化酶的影响。方法选取广州市花都区人民医院重症医学科2019年2月至2020年2月收治的急性脑梗死患者100例作为研究对象,按照随机方式进行分组,对照组50例患者以常规药物治疗为主,观察组50例患者在对照组的基础上采用电针治疗,比较两组的治疗后有效率、治疗前后神经功能缺损评分(NIHSS)、肢体功能评分(FMA)、日常生活能力(barthel)指数、神经元特异性烯醇化酶(NSE)含量、S100B蛋白水平(S100B)、血清高敏C-反应蛋白(hs-CRP)水平、血管内皮生长因子(VEGF)水平、血浆神经肽Y(NPY)、一氧化氮含量(NO)、一氧化氮合成酶活性(NOS)及治疗后不良反应发生情况。结果两组治疗后有效率相比,观察组(96.00%)高于对照组(84.00%)(P<0.05)。观察组治疗后NIHSS评分(14.88±3.74)分低于对照组;观察组FMA评分(58.86±6.12)分、Barthel指数(62.41±20.53)分高于对照组(P<0.05)。观察组治疗后NSE含量(21.24±4.85)μg/L、S100B蛋白水平(0.58±0.13)μg/L、hs-CRP水平(11.42±2.94)mg/L、NPY水平(104.59±51.62)ng/L,低于对照组;VEGF水平(212.02±47.62)ng/L高于对照组(P<0.05)。观察组治疗后NO含量(27.06±2.74)μmol/L、NOS活性(10.98±2.53)U/ml较对照组低(P<0.05)。观察组并发症发生率为6.00%,低于对照组的20.00%(P<0.05)。结论电针治疗急性脑梗死患者效果较好,总有效率较高,可有效改善患者的神经功能缺损程度,提高日常生活能力,降低血清神经元特异性烯醇化酶含量与相关不良反应发生率,有助于改善患者预后。

Objective To investigate the effect of Electroacupuncture on serum neuron specific enolase in patients with acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction treated in the Department of critical medicine of Guangzhou Huadu District People′s Hospital from February 2019 to February 2020 were taken as the research object.All patients were randomly divided into two groups.50 patients in the control group were mainly treated with conventional drugs,and 50 patients in the observation group were treated with electroacupuncture on the basis of the control group Before and after treatment,neurological deficit score(NIHSS),limb function score(FMA),activity of daily living(Barthel)index,neuron specific enolase(NSE)content,S100B protein level(S100b),serum high-sensitivity C-reactive protein(hs-CRP)level,vascular endothelial growth factor(VEGF)level,plasma neuropeptide Y(NPY),nitric oxide content(no)Nitric oxide synthase activity(NOS)and adverse reactions after treatment.Results The effective rate after treatment between the two groups was 96.00%higher in the observation group than 84.00%in the control group(P<0.05).The NIHSS score of the observation group was lower than that of the control group(14.88±3.74)points;FMA score(58.86±6.12)points and Barthel Index(62.41±20.53)points in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of NSE(21.24±4.85)μg/L,S100B protein(0.58±0.13)μg/L,hs-CRP(11.42±2.94)mg/L and NPY(104.59±51.62)ng/L in the observation group were lower than those in the control group;The level of VEGF in the observation group was higher than that in the control group(212.02±47.62)ng/L(P<0.05).After treatment,no content(27.06±2.74)μmol/L and NOS activity(10.98±2.53)U/ml were lower than those in the control group(P<0.05).The incidence of complications in the observation group was 6.00%,which was lower than 20.00%in the control group(P<0.05).Conclusion Electroacupuncture is effective in the treatment of patients with acute cerebral infarction,with a high total effective rate.It can effectively improve the degree of neurological deficit,improve the ability of daily living,reduce the content of serum neuron specific enolase and the incidence of related adverse reactions,and help to improve the prognosis of patients.