细辛脑注射液联合多索茶碱对有创机械通气患者呼吸力学的影响

Effect of asarone injection combined with doxofylline on respiratory mechanics in patients undergoing invasive mechanical ventilation

目的研究静脉注射细辛脑注射液联合多索茶碱对有创机械通气患者呼吸力学等指标的影响。方法将2020年6月至2021年8月湖南少中医院重症医学科接受有创机械通气的60例呼吸衰竭患者随机分为两组,对照组30例使用单独多索茶碱静注治疗,治疗组30例使用细辛脑联合多索茶碱静脉注射治疗,分别观察治疗前和治疗0.5、1、3、6 h和呼吸力学指标(气道峰压、气道平台压、吸气阻力、动态肺顺应性),监测治疗前、治疗后1、3 h血气氧合指数水平。结果治疗组给药后各时间点气道峰压、吸气阻力明显低于对照组(P<0.05),动态肺顺应性、氧合指数明显高于对照组(P<0.05)。结论呼吸衰竭的患者应用细辛脑注射液联合多索茶碱治疗优于多索茶碱单药治疗,更能改善患者的呼吸功能,减少气道阻力和气道内压力,改善动态肺顺应性,提升氧合指数,提升肺通气和换气效率。

Objective To investigate the effect of intravenous asarone injection combined with doxofylline on respiratory mechanics and other indexes in patients undergoing invasive mechanical ventilation.Methods A total of 60 patients with respiratory failure who received invasive mechanical ventilation in the Department of Critical Care Medicine in the Second Affiliated Hospital of Hunan University of Chinese Medicine from June 2020 to August 2021 were randomly divided into two groups.The control group(n=30)were treated with doxofylline infusion alone,and the treatment group(n=30)were treated with asarone combined with doxofylline infusion.The respiratory mechanical indexes(peak airway pressure,airway plateau pressure,inspiratory resistance,and dynamic lung compliance)were observed before treatment,0.5,1,3,6 h after treatment.The blood oxygenation index levels were monitored before treatment,1,3 h after treatment.Results After treatment,the peak airway pressure and inspiratory resistance in the treatment group were significantly lower than those in the control group(P<0.05),and the dynamic lung compliance and oxygenation index in the treatment group were significantly higher than those in the control group(P<0.05).Conclusion Asarone injection combined with doxofylline is superior to doxofylline monotherapy in patients with respiratory failure,which improves respiratory function,reduces airway resistance and intra airway pressure,improves dynamic lung compliance,elevates oxygenation index,and increases lung ventilation and ventilatory efficiency.