磺达肝癸钠和低分子肝素治疗复发性流产的疗效对比

Comparison of curative effect of fondaparinux sodium and low molecular weight heparin on recurrent spontaneous abortion

目的 比较磺达肝癸钠和低分子肝素治疗复发性流产的疗效。方法 选取2021年1—6月就诊于福建医科大学附属闽东医院接受治疗的128例复发性流产患者作为研究对象,采用随机数字表将研究对象分为观察组与对照组,每组各64例。对照组采用低分子肝素钠注射液治疗,观察组采用皮下注射磺达肝癸钠治疗,治疗两周,比较两组的凝血功能、抗心磷脂清除率、激素水平及不良反应发生情况。结果 治疗前两组的PT、TT、APTT及FIB比较,差异无统计学意义(P>0.05),治疗后观察组的PT、TT、APTT长于对照组,FIB低于对照组,差异有统计学意义(P<0.05)。观察组患者的抗心磷脂抗体清除率为73.43%(47/64),明显高于对照组的57.81%(37/64),差异有统计学意义(P<0.05)。治疗前,两组患者的β-h CG、孕激素水平比较,差异无统计学意义(P>0.05)。治疗后两组患者的β-h CG、孕激素水平均较治疗前上升,且观察组高于对照组(P<0.05)。观察组注射部位皮肤反应、肝功能异常发生率明显低于对照组(P<0.05),两组患者的口或鼻黏膜出血、血小板减少和阴道出血发生率比较,差异无统计学意义(P>0.05)。结论 磺达肝癸钠治疗复发性流产患者可改善妊娠结局,不良反应极少,值得临床应用。

Objective To compare the curative effect of fondaparinux sodium and low molecular weight heparin on recurrent spontaneous abortion. Methods A total of 128 patients with recurrent spontaneous abortion who received treatment in our hospital from January to June 2021 were selected as the research subjects. The subjects were divided into the observation group and the control group by random number table, with 64 cases in each group. The control group was treated with low-molecular-weight heparin sodium injection, and the observation group was treated with subcutaneous injection of fondaparinux sodium. The treatment lasted two weeks. The blood coagulation function, anticardiolipin clearance rate, hormone levels, and adverse reactions were compared between the two groups. Results Before treatment,there was no significant difference in PT, TT, APTT, and FIB between the two groups(P>0.05). After treatment, the PT,TT and APTT in the observation group were longer than those in the control group(P<0.05),the FIB level in the observation group was lower than that in the control group(P <0.05). The anticardiolipin antibody clearance rate was73.43%(47/64), which was significantly higher than 57.81%(37/64) in the control group, and the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in the levels of β-h CG and progesterone between the two groups of patients(P>0.05). After treatment, the levels of β-h CG and progesterone in the two groups were higher than before treatment, and the levels of the observation group were higher than the control group(P<0.05). The incidence of skin reaction at the injection site and abnormal liver function in the observation group was significantly lower than that in the control group(P<0.05). There was no significant difference in the incidence of oral and nasal mucosal bleeding, thrombocytopenia, and vaginal bleeding between the two groups(P>0.05). Conclusion Fondaparinux sodium in the treatment of recurrent spontaneous abortion can improve the pregnancy outcome with fewer adverse reactions, which is worthy of clinical application.