利司那肽联合甘精胰岛素对2型糖尿病患者代谢指标的临床获益

Clinical benefits of risnatide combined with insulin glargine on metabolic indexes in patients with type 2 diabetes

目的 探讨利司那肽联合甘精胰岛素对2型糖尿病患者代谢指标临床获益情况。方法 选取2020年1—5月辽宁省朝阳市第二医院内分泌科住院的2型糖尿病患者72例,于午餐前1 h皮下注射利司那肽,晚21∶00皮下注射甘精胰岛素,记录患者基线、1周、12周时一般情况,分析同一患者基线与12周时空腹血糖、早餐后2 h血糖、午餐后2 h血糖、晚餐后2 h血糖、睡前血糖、体重、尿微量白蛋白/肌酐、血尿酸、糖化血红蛋白、总胆固醇、低密度胆固醇、血空腹C肽的变化,以及代谢指标降幅情况、低血糖发生情况。结果 患者基线分别与12周空腹血糖、早餐后2 h血糖、午餐后2 h血糖、晚餐后2 h血糖、睡前血糖、体重、糖化血红蛋白、低密度胆固醇对比,差异均有统计学意义(P<0.05)。3个月内无低血糖发生。结论 甘精胰岛素联合利司那肽治疗2型糖尿病患者,可确切降低患者的餐后血糖、减轻体重,减少胰岛素剂量,且无低血糖发生增加。

Objective To investigate the clinical benefit of risnatide combined with insulin glargine on metabolic indexes in patients with type 2 diabetes. Methods A total of 72 patients with diabetes mellitus in the Department of Endocrinology in Chaoyang Second Hospital in Liaoning Province from January to May 2020 were selected. They were treated with risenatide combined with insulin glargine. The changes of blood glucose on an empty stomach, after breakfast, lunch, 2 hours after dinner, and before bedtime, body weight, urine A/C, uric acid, HbA1C, total cholesterol, lowdensity cholesterol, fasting C-peptide, index reduction, hypoglycemia in the same patient at baseline and 12 weeks after treatment were analyzed. Results There were significant differences in fasting blood glucose, blood glucose 2 hours after breakfast, lunch and dinner, and blood glucose before going to bed, body weight, HbA1C, low-density cholesterol between baseline and 12 weeks after treatment(P<0.05). No hypoglycemia occurred within 3 months. Conclusion Insulin glargine combined with risnatide in the treatment of type 2 diabetic patients can accurately reduce postprandial blood glucose, weight loss, and reduce insulin dose without increasing hypoglycemia.