氟西汀及健康教育治疗男性酒精依赖戒断后情感障碍的疗效

Efficacy of fluoxetine and health education in the treatment of affective disorder after withdrawal of alcohol dependence in men

目的探讨氟西汀及健康教育治疗男性酒精依赖戒断后情感障碍的疗效。方法选取2019年6月至2020年8月经温州康宁医院治疗的酒精依赖戒断后情感障碍患者80例作为研究对象,按照随机数表法分为对照组和研究组,每组各40例,对照组患者给予阿米替林治疗,研究组患者给予氟西汀治疗联合健康教育。治疗6周后,比较两组患者治疗并发症(头晕、口干、心动过速及嗜睡)的发生率;使用躁狂量表(BRMS)评分比较两组患者治疗后的躁狂症状(动作、言语、行为、意志等);采用焦虑自评量表(SAS)评分比较两组患者治疗后的情绪反应(焦虑、害怕、恐慌等);比较两组患者治疗后对血清神经肽Y(NPY)及5-羟色胺(5-HT)水平。比较两组患者治疗后对疾病相关知识的掌握情况。结果研究组患者的BRMS评分及SAS评分分别为(22.63±3.51)分、(35.88±3.32)分,均明显低于对照组的(27.65±4.57)分、(41.70±4.32)分,差异有统计学意义(P<0.05);研究组患者治疗的血清NPY、5-HT水平分别为(140.82±19.36)pg/ml、(3.45±0.69)μg/ml,均明显高于对照组的(111.54±16.79)pg/ml、(2.70±0.67)μg/ml,差异有统计学意义(P<0.05);研究组患者的并发症发生率为12.50%,低于对照组的30.00%,研究组患者对疾病相关知识的熟悉率为85.00%,高于对照组的47.50%,差异有统计学意义(P<0.05)。结论氟西汀及健康教育治疗男性酒精依赖戒断后情感障碍的临床效果显著,实施健康教育能够有效地提高患者对疾病的认识程度,值得临床推广使用。

Objective To investigate the efficacy of fluoxetine and health education in the treatment of affective disorder after withdrawal of alcohol dependence in men.Methods A total of 80 patients with the affective disorder after withdrawal of alcohol dependence treated in our hospital from June 2019 to August 2020 were selected as study subjects,and were divided into the control group(n=40)and the study group(n=40)according to the random number table method.Patients in the control group were treated with amitriptyline,while patients in the study group were treated with fluoxetine combined with health education.After 6 weeks of treatment,the incidence of treatment complications(dizziness,mouth dryness,tachycardia and somnolence)was compared between the two groups.The post-treatment manic symptoms(action,speech,behavior,volition,etc.)were compared between the two groups using the Bech-Rafaelsdn Mania Rating Scale(BRMS)score.The post-treatment emotional reactions(anxiety,fear,panic,etc.)were compared between the two groups using the Self-Rating Anxiety Scale(SAS)score.The levels of serum neuropeptide Y(NPY)and 5-hydroxytryptamine(5-HT)were compared between the two groups.In addition,the mastery level of patients on disease-related knowledge after treatment was compared between the two groups.Results The BRMS and SAS scores of the patients in the study group after treatment were(22.63±3.51)points and(35.88±3.32)points,respectively,which were significantly lower than(27.65±4.57)points and(41.70±4.32)points in the control group,with statistically significant differences(P<0.05).The serum NPY and 5-HT levels of the patients in the study group after treatment were(140.82±19.36)pg/ml and(3.45±0.69)μg/ml,respectively,which were significantly higher than(111.54±16.79)pg/ml and(2.70±0.67)μg/ml in the control group,with statistically significant differences(P<0.05).The incidence of complications in the study group was 12.50%,which was lower than 30.00%in the control group,and the familiarity rate of patients in the study group with disease-related knowledge was 85.00%,which was higher than 47.50%in the control group,with statistically significant differences(P<0.05)Conclusion The combination of fluoxetine and health education has significant clinical efficacy in the treatment of affective disorder after withdrawal of alcohol dependence in men,and the implementation of health education can effectively improve the mastery level of patients on disease-related knowledge.Therefore,this treatment method is worthy of promotion and application in clinical practice.