血清CA199、CEA、CA125在胰腺癌患者中的表达及其表达意义

Expression and significance of serum CA199,CEA and CA125 in patients with pancreatic cancer

目的分析血清CA199、CEA、CA125在胰腺癌患者中的表达,进一步分析血清CA199、CEA、CA125的表达意义。方法选取2018年1月至2021年4月广东省惠州市第一人民医院收治的100例胰腺癌患者为观察组,再选取同期100名健康体检者为对照组。比较两组人群血清糖链抗原199(CA199)、癌胚抗原(CEA)、糖链抗原125(CA125)水平的差异;胰腺癌患者血清CA199、CEA、CA125水平与不同临床特征的关系。结果胰腺癌患者血清CA199(259.63±50.26)U/ml、CEA(13.56±4.28)ng/ml、CA125(80.26±13.24)U/ml水平,明显高于对照组的(10.26±3.24)U/ml、(2.24±0.66)ng/ml、(15.36±4.27)U/ml,差异有统计学意义(P<0.05);血清CA199、CEA、CA125水平在性别、饮酒史、吸烟史、肿瘤部位等方面比较,差异无统计学意义(P>0.05),在年龄、糖尿病、糖尿病病程、肿物直径、临床分期、分化程度、神经浸润、淋巴结转移和远处转移等方面比较,差异有统计学意义(P<0.05)。结论胰腺癌患者血清CA199、CEA、CA125水平明显升高,且与临床特征存在密切的联系;糖尿病患者应积极控制血糖,降低胰腺癌的发生风险。

Objective To analyze the expression of serum CA199,CEA,and CA125 in patients with pancreatic cancer and further analyze the expression significance of serum CA199,CEA and CA125.Methods A total of 100 patients with pancreatic cancer from January 2018 to April 2021 were selected as the observation group in the First People′s Hospital of Huizhou City in Guangdong Province.Then 100 healthy subjects in the same period were selected as the control group.The differences in serum carbohydrate antigen 199(CA199),carcinoembryonic antigen(CEA),and carbohydrate antigen 125(CA125)levels between the two groups were compared.The relationship between serum CA199,CEA,and CA125 levels and different clinical characteristics in patients with pancreatic cancer were compared.Results The serum levels of CA199(259.63±50.26)U/ml,CEA(13.56±4.28)ng/ml,and CA125(80.26±13.24)U/ml in the observation group were significantly higher than those of(10.26±3.24)U/ml,(2.24±0.66)ng/ml,(15.36±4.27)U/ml in the control group,with significant differences(P<0.05).There was no significant difference in serum CA199,CEA and CA125 levels in terms of gender,drinking history,smoking history,and tumor location(P>0.05),but there were significantly different in terms of age,diabetes,duration of diabetes,tumor diameter,clinical-stage,differentiation,nerve invasion,lymph node metastasis,and distant metastasis(P<0.05).Conclusion The serum levels of CA199,CEA,and CA125 in patients with pancreatic cancer are significantly increased,which are closely related to the clinical features.Diabetic patients should actively control blood glucose and reduce the risk of pancreatic cancer.