饮食中有机磷酸酯暴露现状及其对消化系统影响的研究进展

Research progress on dietary organophosphate esters exposure and its effect on digestive system

目的了解饮食中有机磷酸酯(organophosphates esters,OPEs)暴露的现状、对人体健康的影响及其在消化系统疾病发生发展中的作用。方法检索关于OPEs在饮水及食物中的暴露现状及其对消化系统健康影响的相关文献并进行分析及总结。结果OPEs在饮食中存在着长期、广泛、持续的暴露,尽管不同OPEs的暴露水平在时间、空间上存在着差异,但其对消化系统健康的影响不容忽视。OPEs可能通过炎症相关通路的激活与癌症相关基因表达的改变对消化系统损伤及肿瘤发生产生潜在作用。结论OPEs暴露可能是消化系统损伤及肿瘤的潜在危险因素,深入探究其致病机制对高危因素筛查、疾病的预防及保健具有重大意义。

Objective To understand the current situation of dietary organophosphate esters(OPEs)exposure,its effect on human health and its role in the occurrence and development of digestive system disease.Method We searched,analyzed and summarized the relevant literatures on the exposure of OPEs in diet and its effects on digestive system health.Results OPEs had long-term,extensive,and continuous exposure in diet.Although the exposure levels of different OPEs were different in time and space,its impact on digestive system health could not be ignored.OPEs might play a potential role in digestive system injury and tumorigenesis through the activation of inflammation related pathways and the expression change of cancer-related gene.Conclusions OPEs exposure may be a potential risk factor for digestive system injury and tumor.Further exploration of its pathogenic mechanism is of great significance to the screening of high risk factors,disease prevention,and health care.