局部进展期直肠癌治疗新模式:全程新辅助治疗

New pattern of locally advanced rectal cancer treatment:total neoadjuvant therapy

目的探讨全程新辅助治疗(total neoadjuvant therapy,TNT)模式应用于局部进展期直肠癌(locally advanced rectal cancer,LARC)的临床价值、最新研究进展以及临床争议。方法检索有关TNT应用于LARC的临床研究的最新文献并作综述。结果TNT使LARC肿瘤快速降期,提高患者的治疗依从性,从器官保存率、3年无病生存期及病理完全缓解率来说,都相对于传统的方法有优势,是一种极具潜力的治疗模式。结论TNT改善了局部复发及远期生存,对于器官保留意愿强烈的LARC患者,TNT模式是一种良好的治疗选择,具有临床推广价值。

Objective To explore the clinical value,latest research progress,and clinical controversy of total neoadjuvant therapy(TNT)in locally advanced rectal cancer(LARC).Method We searched and reviewed on the latest literatures about studies of the clinical research of TNT in LARC.Results TNT could make the tumor downstage rapidly and improve the patients’treatment compliance.In terms of organ preservation rate,3-year disease-free survival and pathological complete remission rate,TNT had advantages and was a especial potential treatment strategy compared with traditional methods.Conclusions TNT decreases local recurrence rate and improves the long-term survival.For LARC patients with strong desire for organ preservation,TNT is a good treatment choice and has the value of clinical promotion.