中国女性轻度认知障碍的影响因素及其与绝经症状的关系

Relationship between mild cognitive impairment and menopausal symptoms in Chinese women

目的调查中国女性轻度认知障碍(mild cognitive impairment,MCI)的影响因素及其与各种典型绝经症状之间的关系。方法采用蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评估150名志愿者的认知功能,将其中患有轻度认知障碍的61例患者作为病例组(MCI组),认知功能正常的89例患者作为对照组(Non-MCI组)。收集临床、社会人口学和人体测量学数据,用改良Kupperman评分表(Modified Kupperman Index,KMI)评估绝经症状。两组间比较应用t检验和χ^(2)检验。采用二元Logistic回归模型筛选轻度认知功能障碍的危险因素。结果单因素分析显示,两组患者间年龄(P=0.001)、教育水平(P=0.001)、KMI评分(P<0.001)、失眠(P=0.033)与轻度认知功能障碍有关。多因素分析显示,对于年龄不超过55岁的患者,失眠(P=0.032)、头痛(P=0.021)是MCI的独立危险因素,高教育水平(P=0.004)是MCI的独立保护性因素。结论各种更年期症状与MCI之间明确关联,这可能为预防痴呆症提供了新的方向。

Objective To investigate the relationship between mild cognitive impairment(MCI)and various typical menopausal symptoms in Chinese women.Methods A total of 150 volunteers were included in the study,and there were 61 cases(40.7%)in MCI group and 89 cases(59.3%)in non-MCI group.Montreal Cognitive Assessment(MoCA)was used to assess cognitive function.Clinical,sociodemographic and anthropometric data were collected,and menopausal symptoms were evaluated by Modified Kupperman Index(KMI).The two groups were compared by t-test and χ^(2) inspection.Binary Logistic regression model was used to predict the risk factors of mild cognitive impairment.Results Univariate analysis showed that there were significant differences in age(P=0.001),education level(P=0.001),KMI score(P<0.001)and insomnia(P=0.033)between the two groups.Multivariate analysis found that,insomnia(P=0.032)and headache(P=0.021)were independent risk factors,while education(P=0.004)was independent protective risk factor for MCI in patients under 55 years.Conclusion We reported a clear association between various menopausal symptoms and MCI.This may provide novel direction for the prevention of dementia.