摘要
吲唑是一类重要的杂环化合物及中间体,是药物中常见的优势骨架。本文概述了2009年到2021年来酰胺类、磺胺类、胺类、杂环类等吲唑衍生物小分子的合成及抗肿瘤活性。
Indazoles are important heterocyclic compounds and intermediates,which are common dominant skeletons in drugs.The synthesis and anti-tumor activity development of indazole derivatives with amide,sulfonamide,amine,and other heterocycle moieties from 2009 to 2021 were summarized in this article.
作者
陶世林
樊思莉
侯迷
梁俸铭
朱莉
周志旭
王贞超
欧阳贵平
TAO Shi-lin;FAN Si-li;HOU Mi;LIANG Feng-ming;ZHU Li;ZHOU Zhi-xun;WANG Zhen-chao;OU YANG Gui-ping(School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025,China;Drug Synthetic Engineering Laboratory of Guizhou Province,Guiyang 550025,China;Center for Fine Chemical Research and Development,Guizhou University,Guiyang 550025)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2022年第5期937-946,共10页
Chemical Research and Application
基金
国家自然科学基金项目(21867004,22007022)资助
贵州省科技计划项目(黔科合平台人才[2018]5781号)资助。
关键词
吲唑衍生物
抗肿瘤活性
进展
indole derivatives
antibacterial activity
development
