特异性促炎症消退介质在眼表疾病中的研究进展

Research progress of specific pro-resolving mediators in ocular surface diseases

特异性促炎症消退介质(SPM)是一类由多不饱和脂肪酸代谢产生并介导炎症消退反应的脂质介质。SPM信号分子及其受体在眼表组织与细胞高度表达,共同构成内源性SPM网络,对于维持眼表健康和免疫稳态具有重要作用。近年来研究表明,SPM及其类似物在促进角膜伤口愈合与角膜神经再生的同时,还可抑制角膜移植排斥反应、过敏性结膜炎、微生物角膜炎的免疫炎症反应,并有望成为治疗干眼的潜在性药物靶点,同时为眼表疾病的发病机制研究与临床诊治提供了新的思路。本文将就SPM在维持眼表稳态的重要作用及其在多种眼表疾病中的治疗潜力进行综述。

Specific pro-resolving mediators(SPM)are a class of lipid mediators that trigger and orchestrate the resolution of inflammation,which formed in cells by the metabolism of polyunsaturated fatty acids.SPM pathway and receptors are highly expressed inocular surface,and constitute endogenous SPM networks which are important for maintaining ocular surface health and immune homeostasis.Recent evidence indicates that SPM and their analogs are essential mediators in promoting corneal wound healing,corneal nerve regeneration,and inhibiting the immune inflammatory response of corneal transplant rejection,allergic conjunctivitis and microbial keratitis.In addition,they are potential therapeutic drug targets of dry eye disease,and provide novel insight on the research and treatment of ocular surface diseases.Here,we will review and discuss evidence for SPM as important endogenous regulators of ocular surface health and disease and their therapeutic potential.