血管内皮生长因子及上皮-间充质转化在增生性玻璃体视网膜病变发病中的作用

Role of vascular endothelial growth factor and epithelial-mesenchymal transition in the pathogenesis of proliferative vitreoretinopathy

增生性玻璃体视网膜病变(PVR)是一种发生在孔源性视网膜脱离(RRD)自然病程中或复位手术后的严重并发症,常常导致患者视力丧失。目前,临床缺乏有效的治疗方法。PVR病理特征是多种细胞在细胞因子的作用下发生的过度炎症反应和异常增生,最终在视网膜表面形成增殖膜及进一步的牵拉性视网膜脱离(TRD)。对PVR发病机制的深入研究将有助于为其治疗寻找有前景的分子靶标。近年研究发现,血管内皮生长因子(VEGF)及视网膜色素上皮(RPE)细胞的上皮-间充质转化(EMT)在PVR发病中发挥着重要作用。本文就VEGF及RPE细胞EMT在PVR发病中的作用,以及二者的相互联动机制进行了总结,以期为PVR的治疗和临床研究提供新的思路。

Proliferative vitreoretinopathy(PVR)is a serious complication that occurs in the natural history of rhegmatogenous retinal detachment(RRD)or after retinal detachment surgery,often resulting in vision loss.Currently,there has no effective treatment.The pathological characteristics of PVR are the excessive inflammatory response and abnormal proliferation of various cells under the action of cytokines,which eventually form a layer of proliferative membrane around the retinal surface,and further lead to traction retinal detachment(TRD).In-depth studies on the pathogenesis of PVR will help to find promising molecular targets for its treatment.Recent studies have found that vascular endothelial growth factor(VEGF)and the epithelial-mesenchymal transition(EMT)of retinal pigment epithelium(RPE)cells play an important role in the pathogenesis of PVR.This article summarizes the roles of VEGF and RPE cell EMT in the pathogenesis of PVR and the interaction mechanism between them,with the aim to provide new ideas for the treatment and clinical research of PVR.