二联方案对HIV感染者免疫活化的影响

Influence of dual therapy on immune activation among HIV-infected patients

抗逆转录病毒治疗(ART)虽然能有效抑制HIV复制,降低AIDS的发病率和死亡率,但HIV感染者体内仍存在慢性免疫活化。近年来,随着ART方案的不断优化,指南推荐使用的二联方案能否与三联方案一样有效降低免疫活化的水平,是现阶段抗病毒治疗领域热点问题之一。本文总结分析了二联方案免疫活化的相关研究,并通过与三联方案的比较,阐述二联方案实现病毒学疗效后是否存在免疫活化情况。

Although antiretroviral therapy(ART)can effectively inhibit HIV replication,and reduce the morbidity and mortality of AIDS,chronic immune activation still exists in HIV-infected patients.In recent years,with the continuous optimization of ART regimen,whether the dual therapy recommended by the guidelines is as effective as the triple-drug therapy in reducing the level of immune activation has become one of the hot spots in the field of antiviral therapy.In this paper,studies relevant to the immune activation for the dual therapy are reviewed,and the immune activation after the efficacy achievement of the dual therapy comparing with triple-drug therapy is discussed.