SDHA: a key player in T cell-mediated intestinal disease severity

In their recent article in Nature Immunology,Fujiwara et al.identified reduced mitochondrial respiration and increased succinate levels in intestinal epithelial cells(IECs)from several distinct models of T cell-mediated colitis.Their observations point to a specific link between alterations in the mitochondrial complex II component SDHA and the severity of T cell-mediated intestinal diseases and suggest that SDHA dysfunction could be a diagnostic and/or prognostic biomarker in T cell-mediated immunopathology.