莫达非尼的合成研究

Research on the Synthesis of Modafinil

以二苯甲酮(2)为起始原料,经硼氢化钠还原后与五水硫代硫酸钠和氯乙酰胺反应生成Bunte盐缩合得中间体4,4经氧化后得到莫达非尼(1)。产物经^(1)H NMR和MS分析确证,总收率达87%。反应条件温和,收率较高,操作简便,适于工业化生产。

An intermediate■was obtained from the condensation of reduced diphenylmethanone■with Bunte salt formed from the reaction between sodium thiosulfate pentahydrate and chloroacetamide.The target compound1with an overall yield of 87%was obtained from the oxidation reaction of■while the structure of the product was characterized by^(1)H NMR and MS.The advantages of this method include mild reaction condition,satisfactory yields and easy operation.Therefore it will be a promising method for industry.