阿司匹林用于肝细胞癌防治的研究进展

Research progress of aspirin in hepatocellular carcinoma prevention and treatment

原发性肝癌起病隐匿且病死率高,以外科手术为主的综合治疗显著提高了肝癌病人的整体疗效。但靶向及免疫治疗药物价格昂贵,个体差异大,临床仍缺乏有效且费用较低的肝癌辅助治疗药物。阿司匹林已被多项队列研究结果证实能够安全、有效地降低肝癌发病率;同时,在肝癌的辅助治疗上也有较好的疗效。应在开展多项前瞻性临床研究以及阿司匹林治疗肝癌的机制研究的基础上,进一步挖掘其在肝癌预防和治疗中的潜力,从而能够使病人获得更加有效且经济的治疗策略,使更多的肝癌病人受益。

Hepatocellular carcinoma(HCC)is an insidious onset cancer with high mortality.Comprehensive treatment based on surgery has greatly improved the overall survival of HCC patients.However,systemic therapy drugs are always expensive and patients respond differently.Therefore,an effective and cheap auxiliary treatment drugs for HCC is necessary.Aspirin has been proven to be safe and effective in reducing the incidence of HCC by a number of cohort studies.Meanwhile,it has a good performance in auxiliary treatment.It is hoped that more prospective clinical studies and researches are expected to elucidate the mechanism of aspirin in HCC prevention and adjuvant treatment,so that patients can have more effective and economical treatment strategies.