生长分化因子-5在椎间盘退变性疾病的作用

Role of growth differentiation factor-5 in intervertebral disc degeneration

椎间盘退变(intervertebral disc degeneration,IDD)的主要特征是不利因素刺激下多种分子介导的髓核细胞数目减少,细胞外基质(extraellular matrix,ECM)代谢失衡。因此,研究IDD过程中分子表达的变化成为治疗IDD的主要策略之一。近年来,注射生长因子被证明是一种很有前途的治疗IDD的生物疗法;然而,转化生长因子-β等可诱导不必要的血管生长,从而加速IDD的进程;生长分化因子(growth diferentiation factor,GDF)家族在治疗IDD中显示出良好前景。研究表明GDF-5在维持椎间盘(interertebral dise,IVD)的结构和功能方面具有重要作用。这篇综述概述了IDD的病理过程和GDF-5治疗IDD机制的最新研究进展,旨在为延缓IDD提供新的思路。

The main characteristic of intervertebral disc degeneration(IDD)is the reduction of the number of nucleus pulposus cells and the imbalance of the metabolism of extracellular matrix mediated by various molecules under the stimulation of adverse factors.Therefore,studying the changes of molecular expression during IDD has become one of the main strategies for the treatment of IDD.In recent years,injection of growth factors has proved to be a promising biologic therapy for IDD.However,transforming growth factor-β and other factors can induce unnecessary vascular growth,thus accelerating the process of IDD.In contrast,the growth differentiation factor(GDF)family shows promise in the treatment of IDD.Studies have revealed that GDF-5 plays an important role in maintaining the structure and function of intervertebral disc.This review summarizes the pathological process of IDD and the latest research progress on the mechanism of GDF-5 used for treating IDD,aiming to provide new ideas for delaying IDD.