肥胖型PCOS患者的生物学特征和临床特征

Biological and Clinical Characteristics of Obese PCOS Patients

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种内分泌代谢紊乱综合征,临床表现高度异质性。肥胖是PCOS异质性临床表现之一,超过50%的PCOS患者超重或肥胖。肥胖型PCOS主要表现为高雄激素血症、中心型肥胖和糖脂代谢紊乱,非肥胖型PCOS主要表现为黄体生成激素(luteinizing hormone,LH)水平异常升高。尽管肥胖型和非肥胖型PCOS均存在内分泌代谢异常,然而肥胖可加重PCOS糖脂代谢紊乱;肥胖型PCOS还表现脂肪代谢的异常。综述肥胖型PCOS患者的临床特征、性激素水平、糖脂代谢特征,旨在为肥胖型和非肥胖型PCOS患者新的分型诊治提供参考。

Polycystic ovary syndrome(PCOS)is an endocrine and metabolic syndrome with highly heterogeneous manifestations.Obesity is one of the heterogeneous manifestations of PCOS,and more than 50%of PCOS patients are overweight or obese.Obese PCOS is characterized mainly by hyperandrogenism,central obesity and disturbed glucose and lipid metabolism,while non-obese PCOS is characterized mainly by abnormally elevated level of luteinizing hormone(LH).Although the endocrine metabolic abnormalities are present in both obese and non-obese PCOS,obesity exacerbates the disturbed glycolipid metabolism in PCOS patients.The obese PCOS also expresses the abnormality of lipid metabolism.In this review,we summarizethe clinical features,sex hormone levels and glycolipid metabolism of obese PCOS patients,so as to provide a reference for the new diagnosis and treatment of obese and non obese patients with PCOS.