不同剂量盐酸氨溴索治疗老年颅脑外伤肺部感染的效果

Effect of Different Doses of Ambroxol Hydrochloride on Pulmonary Infection in Elderly Patients With Traumatic Brain Injury

目的探究不同剂量盐酸氨溴索防治老年重型颅脑外伤肺部感染的效果观察及安全性。方法本次研究对象从2019年4月至2020年10月来宜兴市第二人民医院就诊的老年重型颅脑外伤患者中选取70例,随机数字表法分为观察组与对照组,每组各35例。对照组给予大剂量盐酸氨溴索,观察组给予小剂量盐酸氨溴索,探究两组患者的治疗效果、用药所致不良反应。结果观察组治疗有效率为80.00%,对照组为77.14%,两组比较,差异无统计学意义(P>0.05);对照组的不良反应发生率为42.86%,观察组为20.00%,观察组的不良反应发生率低于对照组(P<0.05);疾病症状缓解时间,对照组略良好,但与观察组比较,差异无统计学意义(P>0.05);临床指标项行数据采集,两组指标数据基本一致(P>0.05)。结论盐酸氨溴索的使用需要控制剂量,若使用大剂量的药物,不良发应发生率会增加,导致治疗效果适得其反。因此临床上要控制盐酸氨溴索剂量的使用,小剂量的盐酸氨溴索不仅可以减少不良反应发生,还能减少患者出现肺部感染情况。

Objective To investigate the efficacy and safety of different doses of ambroxol hydrochloride in the prevention and treatment of pulmonary infection in the elderly with severe craniocerebral injury.Methods In this study,70 elderly patients with severe traumatic brain injury who came to Yixing Second People′s Hospital from April 2019 to October 2020 were selected.According to the random number table method,these patients were divided into observation and control groups,each with 35 example.The control group was treated with high-dose ambroxol hydrochloride,and the observation group was treated with low-dose ambroxol hydrochloride.The treatment effects and adverse reactions of the two groups of patients were explored.Results The treatment effective rate of the observation group was 80.00%,and the treatment effective rate of the control group was 77.14%.There was no difference in the treatment effective rate of the observation group compared with the control group(P>0.05);the adverse reaction rate of the control group was 42.86%.The incidence of adverse reactions in the observation group was 20.00%,and the incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).The time to relief of disease symptoms was slightly better in the control group,but there was no difference compared with the observation group(P>0.05).Data collection of clinical index items,observation group and control group index data are basically the same(P>0.05).Conclusion The use of ambroxol hydrochloride needs to control the dose.If a large dose of the drug is used,the incidence of adverse reactions will increase,leading to the opposite of the therapeutic effect.Therefore,clinically,the dosage of ambroxol hydrochloride should be controlled.A small dose of ambroxol hydrochloride can not only reduce the incidence of adverse reactions,but also reduce the incidence of lung infections in patients.