孤立性快速眼动睡眠期行为障碍转化为α-突触核蛋白病的预警因素及标志物研究进展

Alarming signs and biomarkers of isolated rapid eye movement behavior disorder transforming intoα-syncleinopathies

α-突触核蛋白病是临床常见的神经系统变性疾病,早期诊断困难。为使患者尽早获得疾病修饰治疗的最佳时机,探索α-突触核蛋白病的预警因素或标志物即显得尤为重要。孤立性快速眼动睡眠期行为障碍(iRBD)是α-突触核蛋白病的前驱症状,在此阶段发挥预警作用可阻止或延缓其转化为α-突触核蛋白病。本文从非运动症状、神经影像学标志物、生物学标志物和基因学等方面阐述iRBD转化为α-突触核蛋白病的预警因素及标志物研究进展。

α-synucleinopathies are a group of common neurodegenerative diseases.Once diagnosed,the disease’s pathology is already in the middle or late stages,and the best timing for disease modification therapy is missed.Thus,it is very important to explore the early warning signs or early markers ofα-synucleinopathies.Isolated rapid eye movement behavior disorder(iRBD)is the prodromal phase ofα-synucleinopathies and may serve as an early warning for future transforming intoα-synucleinopathies at this stage.The early warning mechanisms for the iRBD transforming intoα-synucleinopathies in terms of non-motor symptoms,neuroimaging markers,neuro biological markers,and genetics are illustrated through perspective studies.