基于3.0T磁共振DTI的首发青少年精神分裂症患者脑白质纤维束结构变化研究

Study on the Structure Changes of White Matter Fiber Tracts in Adolescent Schizophrenia Patients Based on 3.0T MRI DTI

目的探究基于3.0T磁共振扩散张量成像(DTI)的首发青少年精神分裂症患者脑白质纤维束结构变化研究。方法选取2018年6月至2019年7月我院放射科诊治的56例首发青少年精神分裂症患者作为观察组,同期60例健康体检者作为对照组。两组均进行3.0T磁共振DTI检查,观察两组认知功能及影像学特征。结果观察组PANSS认知功能评分明显高于对照组,差异显著(P<0.05)。观察组各向异性分数(FA)值降低脑区主要在胼胝体底部、胼胝体膝部、胼胝体压部、扣带束及右上放射冠,且FA值高于对照组的脑区,差异显著(P<0.05)。观察组中脑白质胼胝体体部FA值与阳性症状评分呈正相关(P<0.05),扣带束FA值与阴性症状FA值呈正相关(P<0.05),右上放射冠与一般病理分呈正相关(P<0.05)。结论3.0T磁共振DTI检查首发青少年精神分裂症患者显示脑白质纤维束结构异常,同时脑白质纤维束结构异常容易引起认知功能损伤。

Objective To investigate the changes in the structure of white matter fiber tracts in adolescent schizophrenia patients based on 3.0T nuclear magnetic diffusion tensor imaging(DTI).Methods From June 2018 to July 2019,56 patients with first-onset adolescent schizophrenia diagnosed and treated in our department were enrolled as the observation group,and 60 healthy people examined during the same period were used as the control group.Both groups underwent 3.0T nuclear magnetic resonance DTI examination to observe the cognitive function and imaging characteristics.Results Compared with the cognitive function score of PANSS in the observation group,the control group was significantly lower(P<0.05).The observation group had decreased fractional anisotropy(FA)values,presenting in brain areas of bottom of the corpus callosum,genu of corpus callosum,splenium of corpus callosum,cingulum bundles and upper right radiation crown,but the observation group was higher than the control group(P<0.05).A positive correlation was identified between the FA value of the corpus callosum body and the score of positive symptoms in the observation group(P<0.05),the FA value of the cingulate bundle was positively correlated with the FA value of negative symptoms(P<0.05),and the upper right radiation crown was positively correlated with the general pathological score(P<0.05).Conclusions The 3.0T MRI DTI examination of the first-onset adolescent schizophrenia patients showed abnormal brain white matter fiber tracts structure that is likely to cause cognitive impairment in the meantime.