狼疮肾炎病情活动相关生物标志物的研究进展

Biomarkers related to disease activity in lupus nephritis

狼疮肾炎(lupus nephritis,LN)是系统性红斑狼疮主要并发症之一,发生率高达60%,并且是导致患者死亡的主要原因之一。目前大多数患者经过长期激素或细胞毒性药物治疗仍进展为慢性肾衰竭或终末期肾病。目前LN诊断的金标准为肾穿刺活检,然而因其有创以及当前病理分级的复杂性,肾活检在用于LN诊断时受到一定的限制。因此LN中生物标志物的利用可能对LN的早期诊断及判断患者病情活动起到帮助。本文主要对LN病情活动相关的传统和新型LN生物标志物的研究进展做一综述,从而为临床诊断LN及判断LN患者病情活动提供帮助。

With an incidence rate as high as 60%,lupus nephritis(LN)is one of the major complications of systemic lupus erythematosus.It is also one of leading causes of death.Currently most patients progress to chronic renal failure or end-stage renal disease after long-term hormone or cytotoxic drug dosing.One established gold standard for diagnosing LN is renal biopsy.However,due to its invasiveness and a great complexity of pathological classifications,the diagnostic value of renal biopsy for LN has remained rather limited.Using biomarkers of LN may facilitate an early diagnosis of LN and a gauge of its disease activity.This review summarized the recent advances of researches on traditional and novel biomarkers of LN related to LN disease activity,aiding in clinical diagnosis of LN and determination of LN disease activity.