沙库巴曲缬沙坦钠联合参桂护心汤治疗慢性心力衰竭临床观察

Clinical Observation of Sarcobactrum Valsartan Sodium Combined with Shengui Huxin Decoction in the Treatment of Chronic Heart Failure

目的:探讨沙库巴曲缬沙坦钠联合参桂护心汤治疗慢性心力衰竭(CHF)的临床效果。方法:选取2019年1月至2020年2月期间于许昌市立医院诊治的32例CHF患者,随机编号1~32号,将单数归为对照组,双数归为观察组,各16例。两组均予以常规治疗,在此基础上对照组采用沙库巴曲缬沙坦钠治疗,观察组采用沙库巴曲缬沙坦钠联合参桂护心汤治疗,比较两组治疗前及治疗2个月后中医证候积分、心功能指标、运动耐力及生活质量。结果:两组治疗2个月后,中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗2个月后,左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、明尼苏达心衰生活质量问卷(MLHFQ)评分均低于对照组,左室射血分数(LVEF)、6 min步行试验(6 MWT)水平均高于对照组,差异均有统计学意义(P<0.05)。结论:沙库巴曲缬沙坦钠联合参桂护心汤治疗可改善CHF患者临床症状及心功能,增强运动耐力,改善生活质量。

Objective To investigate the clinical effect of sarcobactrum valsartan sodium combined with Shengui Huxin decoction in the treatment of chronic heart failure(CHF).Methods A total of 32 CHF patients treated in Xuchang Municipal Hospital from January 2019 to February 2020 were randomly numbered from 1 to 32.The odd numbers were assigned to the control group,and the even numbers were assigned to the observation group,with 16 cases in each group.Both groups were given conventional treatment.On this basis,the control group was treated with sarcobactrum valsartan sodium,and the observation group was treated with sarcobactrum valsartan sodium combined with Shengui Huxin decoction.Traditional Chinese mediciner(TCM)syndrome scores,cardiac function indexes,exercise endurance and quality of life of the two groups were compared before treatment and 2 months after treatment.Results After 2 months of treatment,the TCM syndrome scores of the both groups were lower than those of before treatment,and the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).After 2 months of treatment,left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),Minnesota heart failure quality of life questionnaire(MLHFQ)scores in the observation group were lower than those in the control group,left ventricular ejection fraction(LVEF)and 6 min walking test(6 MWT)were all higher than those of the control group.The differences were statistically significant(P<0.05).Conclusion Sarcobactrum valsartan sodium combined with Shengui Huxin decoction can improve the clinical symptoms and cardiac function,enhance exercise endurance,improve the quality of life of CHF patients.