富马酸福莫特罗片对小儿喘息性支气管炎反复发作的疗效

Efficacy of Formoterol Fumarate Tablets on Recurrent Asthmatic Bronchitis in Children

目的:探究富马酸福莫特罗片对小儿喘息性支气管炎反复发作的疗效。方法:将2019年10月至2020年10月期间在河南大学第一附属医院治疗的100例喘息性支气管炎患儿,按治疗方式不同分为常规组(基础治疗与布地奈德联合)和治疗组(在常规组基础上加用富马酸福莫特罗片),各50例。比较两组患儿治疗前后血清白细胞介素-4(IL-4)、白细胞介素-17(IL-17)及其转录因子维甲酸相关核素受体γt(RORγt)、GATA结合蛋白3(GATA-3)水平、临床疗效及复发率。结果:与治疗前比较,两组患儿治疗后RORγt、IL-4、IL-17水平均明显降低,GATA-3水平明显升高;且治疗组患儿治疗后的RORγt水平均低于常规组,GATA-3水平高于常规组,差异均具有统计学意义(P<0.05);治疗组的总有效率为90.00%,明显高于常规组的70.00%,治疗组的复发率为4.00%,明显低于常规组的20.00%,差异均具有统计学意义(P<0.05)。结论:富马酸福莫特罗片联合布地奈德治疗小儿喘息性支气管炎,可有效减轻患儿的炎症反应,且复发率低。

Objective To investigate the effect of formoterol fumarate tablets on recurrent asthmatic bronchitis in children.Methods A total of 100 children with asthmatic bronchitis treated in the First Affiliated Hospital of Henan University from October 2019 to October 2020 were divided into two groups according to different treatment methods,routine group(basic treatment combined with budesonide)and treatment group(formoterol fumarate tablet in addition to routine group),with 50 cases in each group.The levels of serum interleukin-4(IL-4),interleukin-17(IL-17)and their transcription factors retinoic acid receptor-related orphan nuclear receptor γt(RORγt),GATA binding protein 3(GATA-3),clinical efficacy and recurrence rate were compared between the two groups before and after treatment.Results Compared with before treatment,the levels of RORγt,IL-4 and IL-17 in the two groups were significantly decreased after treatment,while the level of GATA-3 was significantly increased;The level of RORγt in the treatment group was lower than that in the routine group,and the level of GATA-3 was higher than that in the routine group,the differences were statistically significant(P<0.05);The total effective rate of the treatment group was 90.00%,significantly higher than 70.00% of the routine group,the recurrence rate of the treatment group was 4.00%,significantly lower than 20.00% of the routine group,the differences were statistically significant(P<0.05).Conclusion Formoterol fumarate tablets combined with budesonide in the treatment of asthmatic bronchitis in children can effectively reduce the inflammatory response,and the recurrence rate is low.