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SALL4蛋白表达在肝细胞癌和肝良性病变区分中的价值 被引量:1

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摘要 肝细胞癌(HCC)是最常见的肝脏恶性原发肿瘤,区分肝癌和肝良性病变对患者病情预测及管理具有非常重要的价值。甲胎蛋白(AFP)是HCC较为常见的血清诊断标志物,但AFP也常见于其他肿瘤患者中,缺乏足够的敏感度和特异性[1,2]。婆罗双树样基因-4(SALL4)已被广泛用作多数生殖细胞瘤(GCTs)标志物,包括原发性和转移性病症[3,4]。
出处 《中西医结合肝病杂志》 CAS 2022年第5期460-462,共3页 Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
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  • 4Tanimura N,Saito M,Ebisuya M,et al. Sternness-related factor Sall4 interacts with transcription factors Oct-3/4 and Sox2 and occupies Oct-Sox elements in mouse embryonic stem cells [J]. J Biol Chem, 2013,288(7) :5027-5038.
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  • 6Li A,Jiao Y,Yong IQ,et al. SALL4 is a new target in endometrial cancer [J]. Oncogene, 2015,34(1 ) : 63-72.
  • 7Yanagihara N ,Kobayashi D ,Kuribayashi K ,et al. Significance of SALIA as a drugresistant factor in lung cancer [J]. Int J Oncol,2015,46(4): 1527-1534.
  • 8Kobayashi D,Kuribayshi K,Tanaka M, et al. SALIA is essential for cancer cell proliferation and is overexpressed at early clinical stages in breast cancer [J]. Int J Oncol, 2011,38(4) :933-939.
  • 9Yue X, Xiao L, Yang Y, et al. High cytoplasmic expression of SALIA predicts a malignant phenotype and poor prognosis of breast invasive ductal carcinoma [J]. Neoplasma, 2015,62(6) :980-988.
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