摘要
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and anabolism to generate cellular energy and structural components.The emerging field of immunometabolism highlights the importance of cellular metabolism for the maintenance and activities of immune cells.Macrophages are embryo-or adult bone marrow-derived leukocytes that are key for healthy tissue homeostasis but can also contribute to pathologies such as metabolic syndrome,atherosclerosis,fibrosis or cancer.Macrophage metabolism has largely been studied in vitro.However,different organs contain diverse macrophage populations that specialize in distinct and often tissue-specific functions.This context specificity creates diverging metabolic challenges for tissue macrophage populations to fulfill their homeostatic roles in their particular microenvironment and conditions their response in pathological conditions.Here,we outline current knowledge on the metabolic requirements and adaptations of macrophages located in tissues during homeostasis and selected diseases.
基金
SKW and the project that gave rise to these results received support in the form of a fellowship from the La Caixa Foundation(ID 100010434)
The fellowship code is LCF/BQ/PR20/11770008
GD is supported by a European Molecular Biology Organization Long-term Fellowship(ALTF 379-2019)
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No.892965
IHM is supported by a La Caixa INPhINIT fellowship(ID 100010434,fellowship code:LCF/BQ/IN17/11620074)
Work in the DS laboratory is funded by the CNIC,by the European Research Council(ERC-2016-Consolidator Grant 725091)
by the Agencia Estatal de Investigación(PID2019-108157RB)
by the Comunidad de Madrid(B2017/BMD-3733 Immunothercan-CM),by Atresmedia(Constantes y Vitales prize),by the Fondo Solidario Juntos(Banco Santander),and by the FundacióLa Maratóde TV3(201723).The CNIC is supported by the Instituto de Salud Carlos III(ISCIII),the MICINN and the Pro CNIC Foundation.
