坏疽性脓皮病发病机制的研究进展

Research progress in pathogenesis of the pyoderma gangrenousum

坏疽性脓皮病(PG)是一种病因不明的嗜中性皮肤病。近年来研究显示,MEFV、PSTPIP-1、NOD2、Ptpn6等易感基因可能与PG相关,中性粒细胞功能障碍、补体系统异常、多种细胞因子(如TNF-α、IL-1α、IL-1β、IL-8、IL-17和IL-25等)分泌的异常亦在PG的发病中起着关键作用。本文就近年来PG发病机制中可能存在的遗传易感因素、免疫异常方面的研究进展作一综述。

Pyoderma gangrenosum(PG)is a neutrophilic dermatosis with unknown origin.Genetic factors,neutrophil dysfunction,complement system dysregulation and aberrant cytokine secretion play important parts in its pathogenesis.This article will make a review of the pathogenesis of the pyoderma gangrenosum from the aspects mentioned above.