非糜烂性反流病的中医研究进展

Research progress of non-erosive reflux disease in traditional Chinese medicine

胃食管反流病(GERD)作为消化科常见病,具有高发病率、全年龄层覆盖、病因复杂等特点。非糜烂性反流病(NERD)为GERD的最常见亚型,约占70%。目前,中医药针对NERD多实、多郁、多热的特点,多治以疏肝、行气、清热之法,并联合抑酸、内镜等治疗,形成了中西医结合治疗方案。中医药治疗NERD的疗效显著,机制研究方面,多认为与降低食管高敏感性、增加食管下括约肌张力、修复食管下端鳞状细胞有关。现根据近年文献对中医药在该病中的应用进行综述,以望为临床提供参考依据。

Gastroesophageal reflux disease(GERD)is considered as one of the most common diseases in gastroenterology department,and it is characterized by high prevalence,full age coverage and complex etiology.Non-erosive reflux disease(NERD)is the most prevalent subtype of GERD,accounting for 70%.At present,according to the characteristics of NERD,which is characterized by more excess,more depression and more heat.There has formed a combination treatment plan with Western medicine in traditional Chinese medicine by dispersing the liver,activating qi and clearing heat,combined with acid-suppression and endoscopy.There is a significant therapeutic effect on NERD in traditional Chinese medicine.In terms of mechanism research,it is generally believed that it is related to reducing esophageal hypersensitivity,increasing the tension of the lower esophageal sphincter,and repairing the lower esophageal squamous cells.In this article,the application of traditional Chinese medicine in NERD is reviewed according to recent literatures,in order to provide a reference for clinical practice.